Discovery Safety Specialists – (Associate) Principal Scientists-AstraZeneca

Beskrivning av jobbet

Would you like to bring your scientific excellence to Drug Safety and Metabolism at AstraZeneca and become a key player in the discovery of safe innovative medicines? Would you like to apply your expertise in a company that is following the science and turns ideas into life changing medicines? Then you might be the one we are looking for! AstraZeneca are looking to recruit two Discovery Safety Specialists to strengthen the Safety Science and Discovery teams within our Respiratory, Inflammation and Autoimmunity (RIA) Safety and Cardiovascular, Renal and Metabolism (CVRM) Safety departments, respectively. The positions will be on an Associate Director/Principal Scientist or Associate Principal Scientist level depending on candidate experience. Both positions are placed at AstraZenecas vibrant R&D site in Gothenburg, Sweden. One of the major challenges in the discovery of innovative medicines is to ensure they are safe enough to provide novel treatments for patients. As part of the global Drug Safety and Metabolism (DSM) function, the Safety Science and Discovery teams within the RIA Safety and CVRM Safety departments develop and apply innovative scientific strategies to drive the design and selection of safe medicines for patients suffering from diseases in the respective therapeutic areas. As true Drug Hunting partners to the Innovative Medicines units, we contribute to the selection of novel drug targets, design of therapeutic concepts, identification and optimization of new chemical series and a range of other modalities (such as peptides, nucleotide-based therapies etc), and selection of novel candidate drugs. We develop and apply cutting edge molecular-, cellular- and in vivo technologies to push the boundaries of predictive safety science and investigative toxicology with our mission in mind: SCIENCE, PASSION, EXPERTISE – Fundamental to selection and delivery of safe and efficacious medicines to patients Within DSM, we put a strong emphasis on talent development. You will be able to develop your scientific leadership by working together with leaders in investigative toxicology, drug discovery, cell biology and predictive safety science. Main Duties and Responsibilities * Contribute to the discovery of innovative treatments for RIA or CVRM diseases. * Be responsible for the safety strategy in multi-disciplinary drug-hunting project teams. You will lead drug safety science and teams to influence project decision making with the aim to deliver molecules with the “Right Safety” profile. * Based on strategic needs versus the discovery project portfolio, develop innovative solutions and research proposals to pursue cutting edge science and technologies in order to optimize and influence safety assessment of novel drug targets. * Design project-specific in vitro and in vivo strategies to predict, assess and mitigate target- and drug-related safety risks and execute through internal and external experimental capabilities. * Engage with world-class experts across our organization to develop, refine and implement innovative experimental strategies and use the data to assess and/or provide mechanistic understanding of safety issues. Requirements * Excellent scientist with a PhD in cell biology, toxicology, pharmacology, systems biology (or related field) and a strong scientific track record. * Experience with design and execution of in vitro and/or in vivo experiments to determine the effects of therapeutics (e.g. small molecules, oligonucleotides, peptides, etc) on biological systems. * Preferably more than 5 years experience from the pharmaceutical industry including: solid understanding of the drug discovery and development process, an appreciation of disciplines within and outside safety and toxicology as well as a track record of successful contributions to progression of drug discovery projects. * Strong communication, presentation and influencing skills across levels/disciplines. * Highly motivated, creative, innovative and reliable scientist with a flexible, collaborative, team-oriented mindset who solves problems in a goal-focused fashion. * A social personality that contributes to an open, positive, collaborative working climate. * Knowledge/experience in one or several of the therapeutic indications that are based in Gothenburg (RIA or CVRM) will be considered an advantage. * Experience in designing and/or executing safety strategies in drug discovery projects will be considered an advantage. Though strong drug discovery and/or development experience is essential for this role, we will consider applications from candidates with fewer years of experience in the pharmaceutical industry for an Associate Principal Scientist position. If you are interested, apply now! For more information please contact Jorrit Hornberg, Senior Director, RIA Safety, jorrit.hornberg(at)astrazeneca.com or Mikael Persson, Director, Safety Science and Discovery, CVRM Safety, mikael.persson(at)astrazeneca.com Welcome with your application no later than August 13th, 2018. AstraZeneca is a global, science-driven biopharmaceutical company. AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. AstraZeneca is an equal opportunity employer.